Week 17 of the 2025 NFL regular season has a lot on the line in its 16 games, from playoff implications to seeding scenarios to draft positions. The wild rather unpredictable league year should continue at the end of the calendar year.

The stakes are high for several teams in the penultimate week of the NFL regular season. Here's how the odds see it going.

ESPN insider's Bills prediction will make Buffalo fans very happy originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. This could be the year. That's a common refrain for Bills Mafia, and thus far, it hasn't come to fruition for the Buffalo Bills.

Here's a look at the latest Super Bowl odds ahead of Week 15. Bet on Super Bowl futures and more NFL action at FanDuel, where new users get $150 in bonus bets if their first wager of $5 or more wins:

We're almost at the finish line of the 2025 NFL regular season, making this our second-to-last NFL Power Rankings of the year. There was plenty of movement near the top of the list after both No. 1 seeds (the Rams and Broncos) lost in Week 16.