Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

For decades, opioids have been the blunt instrument of modern pain care, powerful enough to quiet severe suffering yet risky ...

We report that opioids from the inflamed colon activate δ-opioid receptors (DOPr) in endosomes of nociceptors. Biopsy samples of inflamed colonic mucosa from patients and mice with colitis released ...

July 11 (UPI) --While scientists have long noted a complex connection between a person's addiction to opiates, or "opioid use disorder," and chronic pain, the brain mechanisms linking the two have ...

Researchers used emergent MRI technology to understand the impact of prenatal opioid exposure on early brain development and the neural mechanism behind current medications. “Choose life. Choose a job ...

Synthetic opioids like fentanyl are now the main drivers of fatal overdoses in the US, yet current treatment of the addiction is haphazard and often prohibitive. But new research has uncovered a ...

Naloxone, also known by the brand name Narcan, is one of the most important drugs in the United States’ fight against the opioid crisis. It reverses an opioid overdose nearly instantly, restarting ...

The illegal use of synthetic opioids such as fentanyl and its analogues has killed tens of thousands of people and wreaked devastation on families across the United States. Indeed, in 2017, the White ...

Published results showed partial meniscectomy performed with needle arthroscopy may reduce opioid use in the immediate ...

Cannabis Bioscience International Holdings, Inc. (OTCID: CBIH), a public company trading on the OTC Markets under the ticker ...

Mechanism Exchange & Repair, one of the last manufacturers of newspaper vending machines, is finding their distribution boxes make their way around the country, but instead of newspapers, the cases ...